Bovine 72 kDa Type Iv Collagenase, MMP2 ELISA Kit

SKU: E2183Bo

Size:96 Tests-1 Kit

Background:Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity). PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta-3 on the surface of blood vessels (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:MMP2

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:5.19ng/ml

Detection range:10-2000ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:72 kDa type IV collagenase

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9GLE5

MASS(Da):73,777

GeneID:282872

Synonyms:72 kDa gelatinase;72 kDa type IV collagenase;Matrix Metalloproteinase-2;MMP 2;MMP2;MMP-2

Gene names:MMP2

Standard solution:2400ng/ml