BNIP3L Antibody - Cat. #: CSB-PA002767ESR2HU

SKU: CSB-PA002767ESR2HU

Size :50ul

Clone Number:

Aliases:Adenovirus E1B19k binding protein B5 antibody; Adenovirus E1B19K-binding protein B5 antibody; BCL2/adenovirus E1B 19 kd protein interacting protein 3a antibody; BCL2/adenovirus E1B 19 kDa protein interacting protein 3A antibody; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like antibody; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A antibody; BCL2/adenovirus E1B 19kDa interacting protein 3 like antibody; BNI3L_HUMAN antibody; BNIP3a antibody; BNIP3H antibody; BNIP3L antibody; BNIP3L protein antibody; NIP3 like protein X antibody; NIP3-like protein X antibody; NIP3L antibody; NIX antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O60238

Immunogen:Recombinant Human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like protein (1-187AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:BNIP3L

Research Areas:Cancer; Cardiovascular; Cell biology; Metabolism