BLK Monoclonal Antibody

SKU: BT-MCA2139

Size:100μL

Background:BLK ( B lymphoid tyrosine kinase), with 505-amino acid protein (about 56KDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.

Research_area:Cell Biology

Target_protein:BLK

applications:IHC

Reactivity:Human

Clonality:Monoclonal

Clone ID:9D10B7H6

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:BLK

Immunogen:Purified recombinant fragment of BLK expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):

UniProt accession:P51451

Synonyms:MGC10442

GeneID:640