Bcl-10 Monoclonal Antibody

SKU: BT-MCA0204

Size:100μL

Background:This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

Research_area:Cancer; Metabolism; Cell biology; Signal transduction

Target_protein:BCL10

applications:WB, IHC-p, IF, ICC, FCM, ELISA

Reactivity:Human,Mouse

Clonality:Monoclonal

Clone ID:

Host:Mouse

Isotype:IgG

Gene Symbol/ Name:B-cell lymphoma,leukemia 10

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):N/A

UniProt accession:Human: O95999; Mouse: Q9Z0H7

Synonyms:BCL10; CIPER; CLAP; B-cell lymphoma; leukemia 10; B-cell CLL; lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3; ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog

GeneID:Human: 8915; Mouse: 12042