B7-2/CD86 Polyclonal Antibody

SKU: AN007150L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:CD86

Target Synonym:Activation B7-2 antigen;B72;B7-2;B-lymphocyte activation antigen B7-2;BU63;CD86 antigen;CD86 molecule;CD86;CTLA-4 counter-receptor B7.2;FUN-1;LAB72;MGC34413;T-lymphocyte activation antigen CD86;CD28LG2B7-2 antigen);CD28 antigen ligand 2

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB;IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:O35531

Accession:

Background:B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20‑100 fold higher affinity than CD28 and is involved in the down‑regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through interferon gamma. B7-1 and B7-2 are both members of the immunoglobulin superfamily.

Concentration:1 mg/mL

Immunogen:Recombinant Rat B7-2/CD86 protein expressed by Mammalian

Buffer:PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Purification method:Antigen Affinity Purification

Dilution:WB 1:500-1:1000;IHC 1:200-1:400

Calculated MW:37KDa

ObservedMW:75kDa