ATG8 Antibody, FITC conjugated - Cat. #: CSB-PA739788HC01CZI

SKU: CSB-PA739788HC01CZI

Size :50ug

Clone Number:

Aliases:ATG8 antibody; AUT7 antibody; CAGL0A04675gAutophagy-related protein 8 antibody; Autophagy-related ubiquitin-like modifier ATG8 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Candida glabrata

UniProt ID:Q6FXR8

Immunogen:Recombinant Candida glabrata Autophagy-related protein 8 protein (1-116AA)

Raised in:Rabbit

Species Reactivity:Candida glabrata

Tested Applications:

Background:Ubiquitin-like modifier involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes formation. With ATG4, mediates the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ATG8

Research Areas:Others