AT2B4 rabbit pAb

SKU: ES18219

Size: 100μL

Source:Rabbit

Applications:WB

Reactivity:Human;Rat

Dilution:WB 1：500-2000

Immunogen:Synthesized peptide derived from human AT2B4 AA range: 168-218

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):

Human_gene_id:493

Human_swiss_prot_no:P23634

Subcellular_location:Cell membrane ; Multi-pass membrane protein . Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein .

Other_name:

Background:The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],