APOBEC3D Antibody, Biotin conjugated - Cat. #: CSB-PA846585LD01HU

SKU: CSB-PA846585LD01HU

Size :50ug

Clone Number:

Aliases:A3D antibody; ABC3D_HUMAN antibody; APOBEC3D antibody; APOBEC3DE antibody; APOBEC3E antibody; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3D antibody; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3E pseudogene antibody; ARP6 antibody; bK150C2.9 antibody; BK150C2.9 protein antibody; DNA dC >dU editing enzyme APOBEC 3D antibody; DNA dC->dU-editing enzyme APOBEC-3D antibody; hCG_41704 antibody; HCG41704; isoform CRA_b antibody; Probable DNA dC->dU-editing enzyme APOBEC-3D antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96AK3

Immunogen:Recombinant Human DNA dC->dU-editing enzyme APOBEC-3D protein (250-371AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:APOBEC3D

Research Areas:Epigenetics and Nuclear Signaling; Cell biology