APAF1 Antibody - Cat. #: CSB-PA109273

SKU: CSB-PA109273

Size :100ul

Clone Number:

Aliases:APAF1-interacting protein; APIP; APIP2; CGI-29 protein; MMRP19

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O14727-6

Immunogen:Synthesized peptide derived from Human APAF-1-ALT.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:200, IF:1:100-1:200

Background:This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Keigo Machida, J. Biol. Chem., Apr 2001; 276: 12140 - 12146.
Liam O?nnor, Cancer Res., Mar 2000; 60: 1217 - 1220.
Zeping Wang, Nucleic Acids Res., Apr 2005; 33: 2248 - 2258
Govindaraj Anumanthan, Cancer Res., Nov 2006; 66: 10824 - 10832.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:APAF1

Research Areas:Cancer;Cell biology;Metabolism