Anti-Ugt1a1 Antibody Picoband®

SKU: A01865-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Mouse,Rat

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Mouse
ELISA, 0.1-0.5 μg/ml, -

Gene Name: Ugt1a1

Specificity:

Background: UDP-glucuronosyltransferase 1-1 also known as UGT-1A is an enzyme that in humans is encoded by the UGT1A1 gene. Predicted to enable several functions, including glucuronosyltransferase activity; protein dimerization activity; and retinoic acid binding activity. Predicted to be involved in several processes, including biphenyl catabolic process; cellular glucuronidation; and negative regulation of cellular glucuronidation. Is integral component of plasma membrane. Part of endoplasmic reticulum chaperone complex. Is expressed in alimentary system; nervous system; and urinary system. Human ortholog(s) of this gene implicated in several diseases, including bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; female reproductive organ cancer (multiple); and hepatitis B. Orthologous to human UGT1A1 (UDP glucuronosyltransferase family 1 member A1).

Immunogen: E.coli-derived mouse Ugt1a1 recombinant protein (Position: H57-D248).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. AlFadhli S, Al-Jafer H, Hadi M, Al-Mutairi M, Nizam R (October 2013).The effect of UGT1A1 promoter polymorphism in the development of hyperbilirubinemia and cholelithiasis in hemoglobinopathy patients..PLOS ONE. 8 (10): e77681. 2. Beutler E, Gelbart T, Demina A (July 1998). Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?. Proc Natl Acad Sci USA. 95(14): 8170–4.

Uniprot ID: Q63886

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 55 kDa

Calculated Molecular Weight: 50433 MW

Gene ID: 394436

Protein Name: UDP-glucuronosyltransferase 1A1

Gene Full Name: UDP glucuronosyltransferase 1 family, polypeptide A1

Synonyms: GNT1; HUG BR1; UDPGT; UDPGT 1 1; UGT 1A; UGT1; UGT1 01; UGT1*1; UGT1.1; UGT1A; UGT1A1