Anti-UBAP2L Antibody Picoband®

SKU: A07183-3

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,ICC,IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.1-0.25 μg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: UBAP2L

Specificity:

Background: Ubiquitin-associated protein 2-like is a protein that in humans is encoded by the UBAP2L gene. Ubiquitin-associated protein 2-like (UBAP2L), which contains a ubiquitin-associated (UBA) domain near its N-terminus, has been indicated in the pathogenesis of several human cancers, including multiple myeloma, hepatocellular carcinoma, and malignant ovarian tumors. UBAP2L is closely associated with tumor growth and metastasis. UBAP2L has a key role in glioma cell growth and may act as an oncogene to promote malignant glioma development. UBAP2L also plays an important role in breast cancer cell proliferation and might serve as a potential target for breast cancer treatment. UBAP2L plays a critical role in the maintenance of the metastatic ability of hepatocellular carcinoma (HCC) cells via SNAIL1 Regulation and is predictive of a poor clinical outcome.

Immunogen: E.coli-derived human UBAP2L recombinant protein (Position: A271-S439).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Bordeleau, M.-E., Aucagne, R., Chagraoui, J., Girard, S., Mayotte, N., Bonneil, E., Thibault, P., Pabst, C., Bergeron, A., Barabe, F., Hebert, J., Sauvageau, M., Boutonnet, C., Meloche, S., Sauvageau, G. UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. Blood 124: 2362-2369, 2014. 2. Gross, M. B. Personal Communication. Baltimore, Md. 7/17/2015. 3. Marenholz, I., Zirra, M., Fischer, D. F., Backendorf, C., Ziegler, A., Mischke, D. Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. Genome Res. 11: 341-355, 2001.

Uniprot ID: Q14157

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 150 kDa

Calculated Molecular Weight: 25503 MW

Gene ID: 9898

Protein Name: Ubiquitin-associated protein 2-like

Gene Full Name: ubiquitin associated protein 2 like

Synonyms: UBAP2L; KIAA0144; NICE4; Ubiquitin-associated protein 2-like; Protein NICE-4