Anti-TSG101 Antibody Picoband®

SKU: A01233-2

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IP,Flow Cytometry,ELISA

Application Details: Western blot, 0.1-0.25μg/ml, Human, Mouse, Rat
Immunoprecipitation, 0.5-2 μg/ml, Human
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human
ELISA, 0.1-0.5μg/ml, -

Gene Name: TSG101

Specificity:

Background: TSG101, known as Tumor susceptibility gene 101, is mapped to 11p15. The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. And the protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.

Immunogen: E.coli-derived human TSG101 recombinant protein (Position: E223-K257).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Entrez Gene: TSG101 tumor susceptibility gene 101. 2. Lu Q, Hope LW, Brasch M, Reinhard C, Cohen SN (June 2003). TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7626–31. 3. Sun Z, Pan J, Hope WX, Cohen SN, Balk SP (August 1999). Tumor susceptibility gene 101 protein represses androgen receptor transactivation and interacts with p300. Cancer 86 (4): 689–96.

Uniprot ID: Q99816

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 44 kDa

Calculated Molecular Weight: 123799 MW

Gene ID: 7251

Protein Name: Tumor susceptibility gene 101 protein

Gene Full Name: tumor susceptibility 101

Synonyms: Cell and organelle markers; ESCRT I complex subunit TSG101; Exosome marker; TSG10; TSG101; tumor susceptibility gene 101; VPS23