Anti-Thyroxine Binding Globulin/SERPINA7 Antibody Picoband®

SKU: A02766-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,IHC,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: SERPINA7

Specificity:

Background: Thyroxine-binding globulin (TBG) is a globulin protein that in humans is encoded by the SERPINA7 gene. There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.

Immunogen: E.coli-derived human Thyroxine Binding Globulin/SERPINA7 recombinant protein (Position: R55-R389).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Bertenshaw, R., Takeda, K., Refetoff, S. Sequencing of the variant thyroxine-binding globulin (TBG)-Quebec reveals two nucleotide substitutions. Am. J. Hum. Genet. 48: 741-744, 1991. 2. Buchanan, B. D., Hagen, G. A. Elevated thyroxine-binding globulin with X chromosome linked inheritance. Clin. Endocr. 11: 665-669, 1979. 3. Burr, W. A., Ramsden, D. B., Hoffenberg, R. Hereditary abnormalities of thyroxine-binding globulin concentration: a study of 19 kindreds with inherited increase or decrease of thyroxine-binding globulin. Quart. J. Med. 49: 295-313, 1980.

Uniprot ID: P05543

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 50 kDa

Calculated Molecular Weight: 12252 MW

Gene ID: 6906

Protein Name: Thyroxine-binding globulin

Gene Full Name: serpin family A member 7

Synonyms: SERPINA7; TBG; Thyroxine-binding globulin; Serpin A7; T4-binding globulin