Anti-SNIP1 Antibody Picoband®

SKU: A05476-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: SNIP1

Specificity:

Background: Smad nuclear-interacting protein 1 is a protein that in humans is encoded by the SNIP1 gene. This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED).

Immunogen: E.coli-derived human SNIP1 recombinant protein (Position: H16-E372).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Fujii, M., Lyakh, L. A., Bracken, C. P., Fukuoka, J., Hayakawa, M., Tsukiyama, T., Soll, S. J., Harris, M., Rocha, S., Roche, K. C., Tominaga, S., Jen, J., Perkins, N. D., Lechleider, R. J., Roberts, A. B. SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes. Molec. Cell 24: 771-783, 2006. 2. Gross, M. B. Personal Communication. Baltimore, Md. 6/8/2017. 3. Kim, R. H., Flanders, K. C., Reffey, S. B., Anderson, L. A., Duckett, C. S., Perkins, N. D., Roberts, A. B. SNIP1 inhibits NF-kappa-B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. J. Biol. Chem. 276: 46297-46304, 2001.

Uniprot ID: Q8TAD8

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 46 kDa

Calculated Molecular Weight: 39411 MW

Gene ID: 79753

Protein Name: Smad nuclear-interacting protein 1

Gene Full Name: Smad nuclear interacting protein 1

Synonyms: RP3 423B22.3; SNIP1