Anti-SHANK3 Antibody Picoband®

SKU: A01231-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,Flow Cytometry,ELISA

Application Details: Western blot, 0.1-0.25μg/ml, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human, Rat
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human, Mouse, Rat
ELISA, 0.1-0.5μg/ml, -

Gene Name: SHANK3

Specificity:

Background: SH3 and multiple ankyrin repeat domains 3 (Shank3), also known as proline-rich synapse-associated protein 2 (ProSAP2), is a protein that in humans is encoded by the SHANK3 gene. This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Additionally, Shank proteins play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified.

Immunogen: E.coli-derived human SHANK3 recombinant protein (Position: E1391-H1698).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Entrez Gene: SHANK3 SH3 and multiple ankyrin repeat domains 3. 2. Boeckers TM, Bockmann J, Kreutz MR, Gundelfinger ED (2002). ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic absorbance with an emerging role in human neurological disease.J. Neurochem. 81 (5): 903–10.

Uniprot ID: Q9BYB0

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 180-190 kDa

Calculated Molecular Weight: 123799 MW

Gene ID: 85358

Protein Name: SH3 and multiple ankyrin repeat domains protein 3

Gene Full Name: SH3 and multiple ankyrin repeat domains 3

Synonyms: SH3 and multiple ankyrin repeat domains 3; DEL22q13.3; PROSAP2; PSAP2; SCZD15; SPANK-2; SHANK3