Anti-SCLT1 Antibody Picoband®

SKU: A11417-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: SCLT1

Specificity:

Background: This gene encodes an adaptor protein. Studies of a related gene in rat suggest that the encoded protein functions to link clathrin to the sodium channel protein type 10 subunit alpha protein. The encoded protein has also been identified as a component of distal appendages of centrioles that is necessary for ciliogenesis. Alternative splicing results in multiple transcript variants.

Immunogen: E.coli-derived human SCLT1 recombinant protein (Position: F19-I688). Human SCLT1 shares 76.7% amino acid (aa) sequence identity with both mouse and rat SCLT1.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Adly, N., Alhashem, A., Ammari, A., Alkuraya, F. S. Ciliary genes TBC1D32/C6orf170 and SCLT1 are mutated in patients with OFD type IX. Hum. Mutat. 35: 36-40, 2014. 2. Gurrieri, F., Franco, B., Toriello, H., Neri, G. Oral-facial-digital syndromes: review and diagnostic guidelines. Am. J. Med. Genet. 143A: 3314-3323, 2007. 3. Liu, C., Cummins, T. R., Tyrrell, L., Black, J. A., Waxman, S. G., Dib-Hajj, S. D. CAP-1A is a novel linker that binds clathrin and the voltage-gated sodium channel Nav1.8. Molec. Cell. Neurosci. 28: 636-649, 2005.

Uniprot ID: Q96NL6

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 75 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 132320

Protein Name: Sodium channel and clathrin linker 1

Gene Full Name: sodium channel and clathrin linker 1

Synonyms: CAP1A; hCAP 1A; SAP1; SCLT1