Anti-SCARA5 Antibody Picoband®

SKU: A09571-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/ml, -

Gene Name: SCARA5

Specificity:

Background: Scavenger receptor A5 (SCARA5) is also known as testis expressed scavenger receptor (Tesr). Class A scavenger receptors, including CL-P1, MARCO, SCARA3, and SR-A1, are type II transmembrane proteins that contain a collagenous stalk. Mature human SCARA5 consists of a 60 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 414 aa extracellular domain (ECD) with a spacer, a collagen-like, and a scavenger receptor cysteine-rich (SRCR) domain. Within the ECD, human SCARA5 shares 87% aa sequence identity with mouse and rat SCARA5. It shares 23%?34% aa sequence identity with CL-P1, MARCO, SCARA3, and SR-A1. Alternate splicing generates isoforms that lack the SRCR domain, the transmembrane segment, or the 225 aa spacer region between the membrane and the collagen-like domain. SCARA5 is a cell surface disulfide-linked homotrimer of > 250 kDa. It is highly expressed in testicular Sertoli and germ cells and more weakly in the epithelia of other tissues. During mouse development, SCARA5 expression is attenuated in female embryos at the time of sex determination, whereas it is maintained in the developing testis. SCARA5 is re-expressed in the adult ovary. SCARA5 binds heat-killed bacterial particles but not yeast particles or modified LDL.

Immunogen: E.coli-derived human SCARA5 recombinant protein (Position: K31-R288). Human SCARA5 shares 89.9% amino acid (aa) sequence identity with mouse SCARA5.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Huang, J., Zheng, D.-L., Qin, F.-S., Cheng, N., Chen, H., Wan, B.-B., Wang, Y.-P., Xiao, H.-S., Han, Z.-G. Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. J. Clin. Invest. 120: 223-241, 2010. 2. Jiang, Y., Oliver, P., Davies, K. E., Platt, N. Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells. J. Biol. Chem. 281: 11834-11845, 2006.

Uniprot ID: Q6ZMJ2

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity:

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 50 kDa

Calculated Molecular Weight:

Gene ID: 286133

Protein Name: Scavenger receptor class A member 5

Gene Full Name: scavenger receptor class A member 5

Synonyms: NET33; SCARA5; Scavenger receptor hlg; Tesr