Anti-LZTS2 Antibody Picoband®

SKU: A07806-3

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ICC,IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: LZTS2

Specificity:

Background: The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants.

Immunogen: E.coli-derived human LZTS2 recombinant protein (Position: M1-I669). Human LZTS2 shares 91.7% and 90.5% amino acid (aa) sequence identity with mouse and rat LZTS2, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Cabeza-Arvelaiz, Y., Thompson, T. C., Sepulveda, J. L., Chinault, A. C. LAPSER1: a novel candidate tumor suppressor gene from 10q24.3. Oncogene 20: 6707-6717, 2001. 2. Nagase, T., Nakayama, M., Nakajima, D., Kikuno, R., Ohara, O. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 8: 85-95, 2001. 3. Peng, Y., Clark, C., Luong, R., Tu, W. H., Lee, J., Johnson, D. T., Das, A. Carroll, T. J., Sun, Z. The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development. J. Biol. Chem. 286: 40331-40342, 2011.

Uniprot ID: Q9BRK4

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity:

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 73-75 kDa

Calculated Molecular Weight: 73 kDa

Gene ID: 84445

Protein Name: Leucine zipper putative tumor suppressor 2

Gene Full Name: leucine zipper tumor suppressor 2

Synonyms: LZTS2; KIAA1813; LAPSER1; Leucine zipper putative tumor suppressor 2; hLZTS2; Protein LAPSER1