Anti-LRP5 Antibody Picoband®

SKU: PA2273

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB

Application Details: Western blot, 0.1-0.5μg/ml, Mouse, Rat, Human

Gene Name: LRP5

Specificity: No cross reactivity with other proteins.

Background: Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. It is mapped to 11q13.2. LRP5 is a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with diabetes mellitus type 1 in humans. This protein plays a key role in skeletal homeostasis. In addition to that, the binding of axin to LRP5 is an important part of the Wnt signal transduction pathway, and it also acts as a target for the inhibitory effects of Dickkopf, another developmental protein, on Wnt signaling.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human LRP5, identical to the related mouse and rat sequences.

Clonality: Polyclonal

Contents: Each vial contains antibody formulated with stabilizing components, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
*This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Hey PJ, Twells RC, Phillips MS, Yusuke Nakagawa, Brown SD, Kawaguchi Y, Cox R, Guochun Xie, Dugan V, Hammond H, Metzker ML, Todd JA, Hess JF (Oct 1998). Cloning of a novel member of the low-absorbance lipoprotein receptor family. Gene 216 (1): 103–11. 2. Entrez Gene: LRP5 low absorbance lipoprotein receptor-related protein 5 3. Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., III, Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., Wu, D. Low-absorbance lipoprotein receptor-related protein-5 binds to axin and regulates the canonical Wnt signaling pathway. Molec. Cell 7: 801-809, 2001.

Uniprot ID: O75197

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 179 kDa

Calculated Molecular Weight: 179145 MW

Gene ID: 4041

Protein Name: Low-density lipoprotein receptor-related protein 5

Gene Full Name: LDL receptor related protein 5

Synonyms: BMND1; EVR1; EVR4; HBM; LR3; LRP 5; LRP5; LRP7; OPPG; OPS; OPTA1; VBCH2