Anti-LOXL1 Antibody Picoband®

SKU: PB9719

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: IHC,WB

Application Details: Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human
Western blot, 0.1-0.5μg/ml, Human

Gene Name: LOXL1

Specificity: No cross reactivity with other proteins.

Background: Lysyl oxidase homolog 1, also known as?LOXL1, is an?enzyme?which in humans is encoded by the?LOXL1?gene. This gene encodes a member of the?lysyl oxidase?gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in?collagens?and?elastin. A highly conserved amino acid sequence at the C-terminus?end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The?N-terminus?is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and?chemotaxis?to each member of the family.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human LOXL1, different from the related mouse sequence by one amino acid.

Clonality: Polyclonal

Contents: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg NaN3.
*This antibody is supplied in a stabilized formulation.
Compatibility with conjugation reactions depends on the chemistry of the conjugation method used.
For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Kenyon K, Modi WS, Contente S, Friedman RM (September 1993). A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25. The Journal of Biological Chemistry 268 (25): 18435–7. 2. Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA, Yanagisawa H, Zuo J, Li T (Feb 2004). Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat. Genet. (United States) 36 (2): 178–82. 3. Entrez Gene: LOXL1 lysyl oxidase-like 1.

Uniprot ID: Q08397

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 63 kDa

Calculated Molecular Weight: 63110 MW

Gene ID: 4016

Protein Name: Lysyl oxidase homolog 1

Gene Full Name: lysyl oxidase like 1

Synonyms: LOL; LOXL; LOXL1; Lysyl oxidase homolog 1; lysyl oxidase like 1; Lysyl oxidase like protein 1