Anti-LLGL2 Antibody Picoband®

SKU: A08503-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: LLGL2

Specificity:

Background: The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms.

Immunogen: E.coli-derived human LLGL2 recombinant protein (Position: L102-Q553). Human LLGL2 shares 91.2% amino acid (aa) sequence identity with mouse LLGL2.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Gross, M. B. Personal Communication. Baltimore, Md. 6/24/2019. 2. Saito, Y., Li, L., Coyaud, E., Luna, A., Sander, C., Raught, B., Asara, J. M., Brown, M., Muthuswamy, S. K. LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer. Nature 569: 275-279, 2019. 3. Sripathy, S., Lee, M., Vasioukhin, V. Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development. Molec. Cell. Biol. 31: 2920-2933, 2011.

Uniprot ID: Q6P1M3

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity:

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 120 kDa

Calculated Molecular Weight:

Gene ID: 3993

Protein Name: LLGL scribble cell polarity complex component 2

Gene Full Name: LLGL scribble cell polarity complex component 2

Synonyms: HGL; LGL2; LLGL2