Anti-LGP2/DHX58 Antibody Picoband®

SKU: A04121-2

Size: 100 μg

Storage: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/ml

Gene Name: DHX58

Specificity:

Background: Enables several functions, including ATP hydrolysis activity; RNA binding activity; and zinc ion binding activity. Involved in negative regulation of type I interferon production and regulation of innate immune response. Predicted to be active in cytoplasm.

Immunogen: E.coli-derived human LGP2/DHX58 recombinant protein (Position: A38-S658). Human LGP2/DHX58 shares 78.4% amino acid (aa) sequence identity with mouse LGP2/DHX58.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Cui, Y., Li, M., Walton, K. D., Sun, K., Hanover, J. A., Furth, P. A., Hennighausen, L. The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. Genomics 78: 129-134, 2001. 2. Miyoshi, K., Cui, Y., Riedlinger, G., Robinson, P., Lehoczky, J., Zon, L., Oka, T., Dewar, K., Hennighausen, L. Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. Genomics 71: 150-155, 2001. 3. Saito, T., Hirai, R., Loo, Y.-M., Owen, D., Johnson, C. L., Sinha, S. C., Akira, S., Fujita, T., Gale, M., Jr. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc. Nat. Acad. Sci. 104: 582-587, 2007.

Uniprot ID: Q96C10

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 77 kDa

Calculated Molecular Weight: 77 kDa

Gene ID: 79132

Protein Name: ATP-dependent RNA helicase DHX58

Gene Full Name: DExH-box helicase 58

Synonyms: D11LGP2; D11lgp2e; DHX58; LGP2; Protein D11Lgp2 homolog; RIG I like receptor LGP2; RLR