Anti-KMT6/EZH2 Antibody Picoband®

SKU: A00050-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: ELISA,Flow Cytometry,IP,WB

Application Details: Western blot, 0.1-0.5μg/ml
Immunoprecipitation, 0.5-2 μg/ml
Flow Cytometry(Fixed), 1-3 μg/1x10⁶ cells ELISA, 0.1-0.5μg/ml

Gene Name: EZH2

Specificity: No cross reactivity with other proteins.

Background: Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme encoded by EZH2 gene. It is mapped to 7q36.1. This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.

Immunogen: E.coli-derived human KMT6/EZH2 recombinant protein (Position: E22-T345).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Kim, Kimberly; Roberts, Charles (18 December 2015). Targeting EZH2 in cancer. Nature Medicine. 22: 128–134. 2. Viré E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, et al. (2006). The Polycomb group protein EZH2 ly controls DNA methylation. Nature. 439 (7078): 871–4.

Uniprot ID: Q15910

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 98 kDa

Calculated Molecular Weight: 85,363 MW

Gene ID: 2146

Protein Name: Histone-lysine N-methyltransferase EZH2

Gene Full Name: enhancer of zeste 2 polycomb repressive complex 2 subunit

Synonyms: Enhancer of zeste homolog 2; ENX 1; ENX-1; EZH1; EZH2; KMT6; Lysine N methyltransferase 6