Anti-KCNQ2 Antibody Picoband®

SKU: A01259-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: ELISA,Flow Cytometry,IHC,WB

Application Details: Western blot, 0.25-0.5μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human, Rat
ELISA, 0.1-0.5μg/ml, -

Gene Name: KCNQ2

Specificity:

Background: KCNQ2, also called kv7.2, is a potassium channel protein coded for by the gene KCNQ2. It is mapped to 20q13.33. The KCNQ2 gene encodes a voltage-gated potassium channel that is expressed in the brain. Expression of human KCNQ2 in Xenopus laevis oocytes led to potassium-selective currents that activated slowly with depolarization. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.

Immunogen: E.coli-derived human KCNQ2 recombinant protein (Position: M371-D408).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Biervert, C., Schroeder, B. C., Kubisch, C., Berkovic, S. F., Propping, P., Jentsch, T. J., Steinlein, O. K. A potassium channel mutation in neonatal human epilepsy. Science 279: 403-406, 1998. 2. Entrez Gene: KCNQ2 potassium voltage-gated channel, KQT-like subfamily, member 2 3. Heron, S. E., Cox, K., Grinton, B. E., Zuberi, S. M., Kivity, S., Afawi, Z., Straussberg, R., Berkovic, S. F., Scheffer, I. E., Mulley, J. C. Deletions or duplications in KCNQ2 can cause benign familial neonatal seizures. (Letter) J. Med. Genet. 44: 791-796, 2007.

Uniprot ID: O43526

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 97 kDa

Calculated Molecular Weight:

Gene ID: 3785

Protein Name: Potassium voltage-gated channel subfamily KQT member 2

Gene Full Name: potassium voltage-gated channel subfamily Q member 2

Synonyms: BFNC; EBN; EBN1; ENB1; HNSPC; KCNA11; KCNQ2; KQT like 2; KV7.2; KVEBN1