Anti-Jagged 2/JAG2 Antibody Picoband®

SKU: A01428-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: JAG2

Specificity:

Background: Protein jagged-2, also known as SER2, is a protein that in humans is encoded by the JAG2 gene. It is mapped to 14q32.33. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Notch ligands Delta1 and JAG2 are subject to presenilin-dependent, intramembranous gamma-secretase processing, resulting in the production of soluble intracellular derivatives. JAG2 can promote the growth and dissemination of uveal melanoma cells.

Immunogen: E.coli-derived human Jagged 2/JAG2 recombinant protein (Position: Q22-N1153). Human JAG2 shares 91.1% and 91% amino acid (aa) sequence identity with mouse and rat JAG2, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Asnaghi, L., Handa, J. T., Merbs, S. L., Harbour, J. W., Eberhart, C. G. A role for Jag2 in promoting uveal melanoma dissemination and growth. Invest. Ophthal. Vis. Sci. 54: 295-306, 2013. 2. Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L (April 2000). Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. Genomics 63 (1): 133–8. 3. Ikeuchi, T., Sisodia, S. S. The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent 'gamma-secretase' cleavage. J. Biol. Chem. 278: 7751-7754, 2003. 4. Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J (October 1997). Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol 17 (10): 6057–67.

Uniprot ID: Q9Y219

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 130 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 3714

Protein Name: Protein jagged-2

Gene Full Name: jagged canonical Notch ligand 2

Synonyms: HJ2; JAG2; jagged 2; Jagged2; Protein jagged 2; SER2