Anti-ITM2C Antibody Picoband®

SKU: A08857-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: ITM2C

Specificity:

Background: Integral membrane protein 2C is a protein that in humans is encoded by the ITM2C gene. The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.

Immunogen: E.coli-derived human ITM2C recombinant protein (Position: E33-D226). Human ITM2C shares 94.8% amino acid (aa) sequence identity with mouse and rat ITM2C.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Vidal, R., Calero, M., Revesz, T., Plant, G., Ghiso, J., Frangione, B. Sequence, genomic structure and tissue expression of human BRI(3), a member of the BRI gene family. Gene 266: 95-102, 2001. 2. Wickham, L., Benjannet, S., Marcinkiewicz, E., Chretien, M., Seidah, N. G. Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI(3): binding partners processed by furin. J. Neurochem. 92: 93-102, 2005.

Uniprot ID: Q9NQX7

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity:

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 35 kDa

Calculated Molecular Weight: 30 kDa

Gene ID: 81618

Protein Name: Integral membrane protein 2C

Gene Full Name: integral membrane protein 2C

Synonyms: ITM2C; BRI3; hucep-14; NPD018; PSEC0047; Integral membrane protein 2C; Cerebral protein 14; Transmembrane protein BRI3 [Cleaved into: CT-BRI3]