Anti-Integrin alpha 2/ITGA2 Antibody Picoband®

SKU: A01933-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: ELISA,Flow Cytometry,WB

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: ITGA2

Specificity:

Background: Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene. This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.

Immunogen: E.coli-derived human Integrin alpha 2/ITGA2 recombinant protein (Position: E285-S1181).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Bettaieb, A., Fromont, P., Rodet, M., Godeau, B., Duedari, N., Bierling, P. Br(b), a platelet alloantigen involved in neonatal alloimmune thrombocytopenia. Vox Sang. 60: 230-234, 1991. 2. Carlsson, L. E., Santoso, S., Spitzer, C., Kessler, C., Greinacher, A. The alpha-2 gene coding sequence T807/A873 of the platelet collagen receptor integrin alpha-2/beta-1 might be a genetic risk factor for the development of stroke in younger patients. Blood 93: 3583-3586, 1999. 3. Fan, X., Moltedo, B., Mendoza, A., Davydov, A. N., Faire, M. B., Mazutis, L., Sharma, R., Pe'er, D., Chudakov, D. M., Rudensky, A. Y. CD49b defines functionally mature Treg cells that survey skin and vascular tissues. J. Exp. Med. 215: 2796-2814, 2018.

Uniprot ID: P17301

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 165 kDa

Calculated Molecular Weight:

Gene ID: 3673

Protein Name: Integrin alpha-2

Gene Full Name: integrin subunit alpha 2

Synonyms: ITGA2; CD49B; Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD antigen CD49b