Anti-Human respiratory syncytial virus(RSV) Glycoprotein G/RSV-G Monoclonal Antibody

SKU: E-AB-V1274

Size::20μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Virus Antibodies

Abbreviation:

Target Synonym:G;Glycoprotein

Research Areas:

Conjugation:Unconjugated

Host:Mouse

Species reactivity:RSV

Application:ELISA

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:9H2G5C6

UNIProt ID:

Accession:

Background:Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneumovirus of the family paramyxoviridae. Like other members of the family, HRSV has two major surface glycoproteins (G and F) that play important roles in the initial stages of the infectious cycle. HRSV G protein is a type II glycoprotein of 289-299 amino acids (depending on the virus strain) with a signal/anchor hydrophobic domain and is extensively modified by the addition of both N-and O-linked oligosaccharides to achieve the mature form of 8-9 kDa. The C-terminal ectodomain of the G protein has a central region and four cysteines which are conserved in all HRSV isolates and have been proposed as the putative receptor binding site. The G protein mediates attachment of the virus to the host cell membrane by interacting with heparan sulfate, initiating the infection. As similar to mucins in amino acid compositions, the RSV G protein can interact with host CX3CR1, the receptor for the CX3C chemokine fractalkine, and thus modulates the immune response and facilitate infection. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. Unlike the other paramyxovirus attachment proteins, HRSV-G lacks both neuraminidase and hemagglutinating activities.

Concentration:1mg/mL

Immunogen:Recombinant RSV (A, rsb1734) glycoprotein G / RSV-G Protein (95% Homology) (His Tag)

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A Affinity

Dilution:ELISA 1:1000-1:2000

Calculated MW:

ObservedMW: