Anti-Human FGFR2 Reference Antibody (Bemarituzumab, RUO)

SKU: HB863016

Size:100ug

Description:Bemarituzumab (bema), a first-in-class humanized IgG1 monoclonal antibody, selectively binds to the 2b isoform of the fibroblast growth factor receptor (FGFR2b). Bemarituzumab (FPA144) is a first-in-class humanized immunoglobulin G1 monoclonal antibody specific to the splice-variant FGFR2b that inhibits binding of the ligands FGF7, FGF10, and FGF22. Specifically, bemarituzumab does not inhibit binding of FGF23, the ligand responsible for phosphate and vitamin D metabolism, thereby potentially avoiding the risk of hyperphosphatemia associated with pan-FGFR tyrosine kinase inhibitors. Bemarituzumab is also glycoengineered for increased affinity for the human Fc gamma RIII receptor expressed on natural killer cells, enabling enhanced antibody-dependent cell-mediated cytotoxicity.

Host species:Humanized

Tested applications:

Species reactivity:Human

Form:Liquid

Storage buffer:0.01M PBS, pH 7.4.

Purity:>95% purity as determined by SDS-PAGE.

Clonality:Monoclonal

Isotype:IgG1-kappa

Applications:ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Target:K-sam, KSAM, CD332, Keratinocyte growth factor receptor, Fibroblast growth factor receptor 2, FGFR-2, FGFR2, KGFR, BEK

Purification:Protein A/G purified from cell culture supernatant.

Endotoxin level:Please contact us for this information.

Expression system:Mammalian Cells

Accession:P21802

Stability and Storage:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

Reconstitution:

Background:

Alternative Names:FPA144, FPA-144, FPA114-A, 1952272-74-0

Clone ID:

Species:

Note:For research use only. Not suitable for clinical or therapeutic use.