Anti-FOXE1 Picoband® Antibody

SKU: A02831-5

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5μg/ml, Human
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human
ELISA, 0.1-0.5μg/ml, -

Gene Name: FOXE1

Specificity: No cross reactivity with other proteins.

Background: Forkhead box protein E1 is a protein that in humans is encoded by the FOXE1 gene. It is mapped to 9q22.33. This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4.

Immunogen: E.coli-derived human FOXE1 recombinant protein (Position: M1-M373).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Carre, A., Castanet, M., Sura-Trueba, S., Szinnai, G., Van Vliet, G., Trochet, D., Amiel, J., Leger, J., Czernichow, P., Scotet, V., Polak, M. Polymorphic length of FOXE1 alanine stretch: evidence for genetic susceptibility to thyroid dysgenesis. Hum. Genet. 122: 467-476, 2007. 2. Trueba, S. S., Auge, J., Mattei, G., Etchevers, H., Martinovic, J., Czernichow, P., Vekemans, M., Polak, M., Attie-Bitach, T. PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations. J. Clin. Endocr. Metab. 90: 455-462, 2005. 3. Venza, I., Visalli, M., Parrillo, L., De Felice, M., Teti, D., Venza, M. MSX1 and TGF-beta-3 are novel target genes functionally regulated by FOXE1. Hum. Molec. Genet. 20: 1016-1025, 2011.

Uniprot ID: O00358

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 38 kDa

Calculated Molecular Weight: 38 kDa

Gene ID: 2304

Protein Name: Forkhead box protein E1

Gene Full Name: forkhead box E1

Synonyms: FKHL15; Forkhead box protein E1; Forkhead box protein E2; FOXE1; FOXE2; HFKH4; HFKL5; HNF 3/fork head like protein 5; Thyroid transcription factor 2; TITF2; TTF 2; TTF2