Anti-FLIP/CFLAR Antibody Picoband®

SKU: A01295-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: ELISA,IHC,WB

Application Details: Western blot, 0.1-0.5μg/ml
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml
ELISA, 0.1-0.5μg/ml

Gene Name: CFLAR

Specificity: No cross reactivity with other proteins.

Background: CASP8 and FADD-like apoptosis regulator, also called c-FLIP (FLICE-like inhibitory protein), is a protein that in humans is encoded by the CFLAR gene. The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.

Immunogen: E. coli-derived human FLIP recombinant protein (Position: M1-D376).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). Inhibition of death receptor signals by cellular FLIP. Nature. 388 (6638): 190–5. 2. Shu HB, Halpin DR, Goeddel DV (Jul 1997). Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. 6 (6): 751–63.

Uniprot ID: O15519

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 43 kDa

Calculated Molecular Weight:

Gene ID: 8837

Protein Name: CASP8 and FADD-like apoptosis regulator

Gene Full Name: CASP8 and FADD like apoptosis regulator

Synonyms: c FLIP; c FLIPL; c FLIPR; c FLIPS; CASH; CASP8AP1; Caspase eight related protein; Caspase homolog; Casper; CFLAR; CFLAR/FLIP; CLARP; FLAME; FLAME 1; FLAME1; FLIP; I FLICE; Inhibitor of FLICE; MRIT; Usurpin