Anti-CRMP4/Dpysl3 Antibody Picoband®

SKU: A05960-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Rat

Applications: WB

Application Details: Western blot, 0.25-0.5 μg/ml, Rat

Gene Name: Dpysl3

Specificity:

Background: Dihydropyrimidinase-related protein 3 is an enzyme that in humans is encoded by the DPYSL3 gene. This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of rat CRMP4/Dpysl3, which shares 93.3% amino acid (aa) sequence identity with both human and mouse CRMP4/Dpysl3.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Blasco, H., Bernard-Marissal, N., Vourc'h, P., Guettard, Y. O., Sunyach, C., Augereau, O., Khederchah, J., Mouzat, K., Antar, C., Gordon, P. H., Veyrat-Durebex, C., Besson, G., Andersen, P. M., Salachas, F., Meininger, V., Camu, W., Pettmann, B., Andres, C. R., Corcia, P., the French ALS Study Group. A rare motor neuron deleterious missense mutation in the DPYSL3 (CRMP4) gene is associated with ALS. Hum. Mutat. 34: 953-960, 2013. 2. Byk, T., Dobransky, T., Cifuentes-Diaz, C., Sobel, A. Identification and molecular characterization of Unc-33-like phosphoprotein (Ulip), a putative mammalian homolog of the axonal guidance-associated unc-33 gene product. J. Neurosci. 16: 688-701, 1996. 3. Gaetano, C, Matsuo, T., Thiele, C. J. Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells. J. Biol. Chem. 272: 12195-12201, 1997.

Uniprot ID: Q62952

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 62 kDa

Calculated Molecular Weight: 80420 MW

Gene ID: 25418

Protein Name: Dihydropyrimidinase-related protein 3

Gene Full Name: dihydropyrimidinase-like 3

Synonyms: CRMP 4; CRMP4; dihydropyrimidinase like 3; DPYSL3; DRP 3; DRP3; LCRMP; ULIP; ULIP 1; ULIP1; Unc 33 like phosphoprotein 1