Anti-CD168/HMMR Antibody Picoband®

SKU: PA1592

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: IHC,WB

Application Details: Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human
Western blot, 0.1-0.5μg/ml, Human

Gene Name: HMMR

Specificity: No cross reactivity with other proteins.

Background: HMMR, Hyaluronan-mediated motility receptor, is a protein which in humans is encoded by the HMMR gene. RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan, HMMR is less well studied than the main hyaluronan (HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum/Golgi complex, HMMR does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence. HMMR normally is localized inside the cell and is only release by certain, poorly defined stimuli. The transport of HMMR to the extracellular space still is unclear but may involve transport channels or proteins, flippase activity, or exocytosis. Intracellularly, HMMR associates with microtubules and, working with BRCA1 and BARD1, plays a role in the regulation of mitosis. Extracellularly, HMMR associates with CD44, and upon binding to HA, activates intracellular signaling pathways. Variants of HMMR caused by alternative splicing have been observed, but not thoroughly studied.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CD168.

Clonality: Polyclonal

Contents: Each vial contains antibody formulated with stabilizing components, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
*This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Entwistle, J., Zhang, S., Yang, B., Wong, C., Li, Q., Hall, C. L., Jingbo, A., Mowat, M., Greenberg, A. H., Turley, E. A.Characterization of the murine gene encoding the hyaluronan receptor RHAMM.Gene 163: 233-238, 1995. 2. Hall, C., Yang, B., Yang, X., Zhang, S., Turley, M., Samuel, S., Lange, L. A., Wang, C., Curpen, G. D., Savani, R. C., Greenberg, A. H., Turley, E. A.Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation.Cell 82: 19-28, 1995. 3. Savani, R. C., Wang, C., Yang, B. H., Zhang, S. W., Kinsella, M. G., Wight, T. N., Stern, R., Nance, D. M., Turley, E. A.Migration of bovine aortic smooth muscle cells after wounding injury: the role of hyaluronan and RHAMM.J. Clin. Invest. 95: 1158-1168, 1995.

Uniprot ID: O75330

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 84 kDa

Calculated Molecular Weight: 84100 MW

Gene ID: 3161

Protein Name: Hyaluronan mediated motility receptor

Gene Full Name: hyaluronan mediated motility receptor

Synonyms: CD168; HMMR; HMMR-Specific; IHABP; RHAMM