Anti-CACNA1S Antibody Picoband®

SKU: A03006-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat,Monkey

Applications: ELISA,Flow Cytometry,IHC,WB

Application Details: Western blot, 0.25-0.5μg/ml, Mouse, Rat, Monkey
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human, Rat
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human
ELISA, 0.1-0.5μg/ml, -

Gene Name: CACNA1S

Specificity:

Background: Cav1.1 also known as the calcium channel, voltage-dependent, L type, alpha 1S subunit, (CACNA1S), is a protein which in humans is encoded by the CACNA1S gene. This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility.

Immunogen: E.coli-derived human CACNA1S recombinant protein (Position: E1583-C1779).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.005mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500μg/ml.

Reference: 1. Boerman, R. H., Ophoff, R. A., Links, T. P., van Eijk, R., Sandkuijl, L. A., Elbaz, A., Vale-Santos, J. E., Wintzen, A. R., van Deutekom, J. C., Isles, D. E., Fontaine, B., Padberg, G. W., Frants, R. R. Mutation in DHP receptor alpha-1 subunit (CACLN1A3) (sic) gene in a Dutch family with hypokalaemic periodic paralysis. J. Med. Genet. 32: 44-47, 1995. 2. Campbell, K. P., Leung, A. T., Sharp, A. H. The biochemistry and molecular biology of the dihydropyridine-sensitive calcium channel. Trends Neurosci. 11: 425-430, 1988. 3. Catterall, W. A. Functional subunit structure of voltage-gated calcium channels. Science 253: 1499-1500, 1991.

Uniprot ID: Q13698

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 220 kDa

Calculated Molecular Weight:

Gene ID: 779

Protein Name: Voltage-dependent L-type calcium channel subunit alpha-1S

Gene Full Name: calcium voltage-gated channel subunit alpha1 S

Synonyms: CACH1; CACN1; CACNA1S; CACNL1A3; Cav1.1; CCHL1A3; HOKPP; hypoPP; MHS5