Anti-Butyrylcholinesterase/BCHE Antibody Picoband®

SKU: PB9526

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Mouse

Applications: WB

Application Details: Western blot, 0.1-0.5μg/ml, Mouse

Gene Name: Bche

Specificity: No cross reactivity with other proteins.

Background: Butyrylcholinesterase (BCHE, or BuChE), also known as pseudocholinesterase or plasma cholinesterase, is a non-specific cholinesterase enzyme that hydrolyses many different choline esters. In humans, it is found primarily in the liver and is encoded by the BCHE gene. Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.

Immunogen: E.coli-derived mouse BCHE recombinant protein (Position: K263-E571). Mouse BCHE shares 78% amino acid (aa) sequence identity with human BCHE.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Allderdice PW, Gardner HA, Galutira D, Lockridge O, LaDu BN, McAlpine PJ (Oct 1991). The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26. Genomics 11 (2): 452–4. 2. Jasmin L (2013-05-28). Cholinesterase - blood. University of Maryland Medical Center. 3. Pohanka M (2013). Butyrylcholinesterase as a biochemical marker. Bratislavské Lekárske Listy 114 (12): 726–734.

Uniprot ID: Q03311

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 85-90 kDa

Calculated Molecular Weight: 68462 MW

Gene ID: 12038

Protein Name: Cholinesterase

Gene Full Name: butyrylcholinesterase

Synonyms: Acylcholine acylhydrolase; BCHE; Butyrylcholine esterase; butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase; E1; Pseudocholinesterase; BCHED; CHE2