Anti-BSCL2/Seipin Antibody Picoband®

SKU: A02753-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/ml, -

Gene Name: BSCL2

Specificity:

Background: Seipin is a protein that in humans is encoded by the BSCL2 gene. This gene encodes the multi-pass transmembrane protein protein seipin. This protein localizes to the endoplasmic reticulum and may be important for lipid droplet morphology. Mutations in this gene have been associated with congenital generalized lipodystrophy type 2 or Berardinelli-Seip syndrome, a rare autosomal recessive disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U-like 2).

Immunogen: E.coli-derived human BSCL2/Seipin recombinant protein (Position: A87-P231).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Agarwal, A. K., Garg, A. Seipin: a mysterious protein. Trends Molec. Med. 10: 440-444, 2004. 2. Auer-Grumbach, M., Loscher, W. N., Wagner, K., Petek, E., Korner, E., Offenbacher, H., Hartung, H.-P. Phenotypic and genotypic heterogeneity in hereditary motor neuronopathy type V: a clinical, electrophysiological and genetic study. Brain 123: 1612-1623, 2000. 3. Auer-Grumbach, M., Schlotter-Weigel, B., Lochmuller, H., Strobl-Wildemann, G., Auer-Grumbach, P., Fischer, R., Offenbacher, H., Zwick, E. B., Robl, T., Hartl, G., Hartung, H.-P., Wagner, K., Windpassinger, C., Austrian Peripheral Neuropathy Study Group. Phenotypes of the N88S Berardinelli-Seip congenital lipodystrophy 2 mutation. Ann. Neurol. 57: 415-424, 2005.

Uniprot ID: Q96G97

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 46 kDa

Calculated Molecular Weight: 12252 MW

Gene ID: 26580

Protein Name: Seipin

Gene Full Name: BSCL2 lipid droplet biogenesis associated, seipin

Synonyms: BSCL2; Seipin; GNG3LG; HMN5; HMN5C; PELD; SPG17