Anti-Beta-HCG CGB Antibody (Monoclonal, PC-2)

SKU: MA1111

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: IHC

Application Details: Immunohistochemistry (Paraffin-embedded Section), 2μg/ml, Human

Gene Name: CGB

Specificity: No cross reactivity with other proteins.

Background: beta-HCG (beta-Human Chorionic Gonadotropin), also termed as Chorionic Gonadotropin, Beta Chain (CGB). It is encoded by a multigene cluster composed of six homologous sequences. And in the family of beta-containing glycoprotein hormones, beta-HCG is unique in that it contains an extension of 29 amino acids at its COOH end. beta-HCG is mapped to 19q13.32 and expressed in trophoblast and various malignant tumors promotes cellular motility in vivo. beta-HCG has a novel function in uterine adaptation to early pregnancy as well as in tumor development and underline the importance of HCG as an as yet unrecognized angiogenic factor.

Immunogen: Purified human Chorionic Gonadotropin.

Clonality: Monoclonal

Contents: Mouse IgG in stabilizing components, 1.2% sodium acetate and 0.01mg NaN3. *This antibody is supplied in a stabilized formulation.
Compatibility with conjugation reactions depends on the chemistry of the conjugation method used.
For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Ascites

Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Reference: 1. Bo, M.; Boime, I. : Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. J. Biol. Chem. 267: 3179-3184, 1992.) 2. Policastro, P.; Ovitt, C. E.; Hoshina, M.; Fukuoka, H.; Boothby, M. R.; Biome, I. : The beta-subunit of human chorionic gonadotropin is encoded by multiple genes. J. Biol. Chem. 258: 11492-11499, 1983. 3. Zygmunt, M.; Herr, F.; Keller-Schoenwetter, S.; Kunzi-Rapp, K.; Munstedt, K.; Rao, C. V.; Lang, U.; Preissner, K. T. : Characterization of human chorionic gonadotropin as a novel angiogenic factor. J. Clin. Endocr. Metab. 87: 5290-5296, 2002.

Uniprot ID: P01233

Host: Mouse

Concentration: Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Conjugate:

Cross Reactivity: Cross-reactivities with LH, FSH and TSH are less than 0.3%.

Isotype: Mouse IgG1

Phospho_site:

Clone Number: Clone: PC-2

Observed Molecular Weight: 55 kDa

Calculated Molecular Weight: 17739 MW

Gene ID: Human(1082)

Protein Name: Choriogonadotropin subunit beta 3

Gene Full Name: chorionic gonadotropin subunit beta 3

Synonyms: CGB3; CGB5; CGB7; CGB8; hCGB; CHORIONIC GONADOTROPIN, BETA POLYPEPTIDE 3