Anti-Band 4.1-like protein 1 EPB41L1 Antibody Picoband®

SKU: PA2266

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB

Application Details: Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat

Gene Name: EPB41L1

Specificity: No cross reactivity with other proteins.

Background: Band 4.1-like protein 1 is a protein that in humans is encoded by the EPB41L1 gene. This gene is mapped to 20q11.23. It is found that a heterozygous missense mutation in the EPB41L1 gene causing nonsyndromic intellectual disability. This gene may function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. EPB41L1 has been shown to interact with ITPR1, Dopamine receptor D2, Dopamine receptor D3, CENTG1 and Nuclear mitotic apparatus protein 1.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human EPB41L1, different from the related mouse and rat sequences by one amino acid.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Binda, Alicia V; Kabbani Nadine, Lin Ridwan, Levenson Robert (September 2002). D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N. Mol. Pharmacol. (United States) 62 (3): 507–13. 2. Hamdan, F. F., Gauthier, J., Araki, Y., Lin, D.-T., Yoshizawa, Y., Higashi, K., Park, A.-R., Spiegelman, D., Dobrzeniecka, S., Piton, A., Tomitori, H., Daoud, H., and 22 others. Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability. Am. J. Hum. Genet. 88: 306-316, 2011. Note: Erratum: Am. J. Hum. Genet. 88: 516 only, 2011. 3. Kim AC, Van Huffel C, Lutchman M, Chishti AH (June 1998). Radiation hybrid mapping of EPB41L1, a novel protein 4.1 homologue, to human chromosome 20q11.2-q12. Genomics 49 (1): 165–6.

Uniprot ID: Q9H4G0

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 100-130 kDa

Calculated Molecular Weight: 99 kDa

Gene ID: 2036

Protein Name: Band 4.1-like protein 1

Gene Full Name: erythrocyte membrane protein band 4.1 like 1

Synonyms: 4.1N; Band 4.1 like protein 1; EPB41L1; KIAA0338; Neuronal protein 4.1