Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband®

SKU: PB9470

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Monkey,Mouse,Rat

Applications: IHC,WB

Application Details: Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human
Western blot, 0.1-0.5μg/ml, Human, Monkey, Mouse, Rat

Gene Name: AGTR1

Specificity: No cross reactivity with other proteins.

Background: AGTR1 is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human AGTR1, different from the related mouse and rat sequences by one amino acid.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Entrez Gene: AGTR1 angiotensin II receptor, type 1. 2. Catt KJ, Mendelsohn FA, Millan MA, Aguilera G (1984). The role of angiotensin II receptors in vascular regulation. J. Cardiovasc. Pharmacol. 6(Suppl 4): S575–86. 3. Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (2007). Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Clin. Sci. 112 (8): 417–28.

Uniprot ID: P30556

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 50 kDa

Calculated Molecular Weight: 41061 MW

Gene ID: 185

Protein Name: Type-1 angiotensin II receptor

Gene Full Name: angiotensin II receptor type 1

Synonyms: AG2S; AGTR1; AGTR1A; AGTR1B; Angiotensin II type 1 receptor; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R; Type 1 angiotensin II receptor