AMPKβ2 rabbit pAb

SKU: ES20834

Size: 100μL

Source:Rabbit

Applications:WB

Reactivity:Human;Mouse;Rat

Dilution:WB: 1:1000-2000

Immunogen:Recombinant Protein of AMPKβ2

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:

Observed_band(KD):30kD

Human_gene_id:5565

Human_swiss_prot_no:O43741

Subcellular_location:nucleoplasm,cytosol,nucleotide-activated protein kinase complex,

Other_name:PRKAB2; 5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2

Background:The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],