AMPK alpha2 Polyclonal Antibody

SKU: D-AB-10161L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:AMPK

Target Synonym:5'-AMP-activated protein kinase catalytic subunit alpha-2;AAPK2;ACACA kinase;Acetyl-CoA carboxylase kinase;AMPK alpha 2 chain;AMPK subunit alpha-2;AMPK2;AMPKa2;AMPKalpha2;HMGCR kinase;Hydroxymethylglutaryl-CoA reductase kinase;PRKAA;PRKAA2;Protein kinase AMP activated alpha 2 catalytic subunit;Protein kinase AMP activated catalytic subunit alpha 2

Research Areas:Cancer;Cardiovascular;Metabolism;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC;IF

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q09137

Accession:

Background:The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Concentration:1 mg/mL

Immunogen:Recombinant Rat Ampk2 protein expressed by E.coli

Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4

Purification method:Antigen Affinity Purification

Dilution:WB 1:500-1:1000;IHC 1:100-1:200;IF 1:100-1:400

Calculated MW:62 kDa

ObservedMW:62 kDa