ALOX15 Antibody, Biotin conjugated - Cat. #: CSB-PA001621LD01HU

SKU: CSB-PA001621LD01HU

Size :50ul

Clone Number:

Aliases:15 lipoxygenase 1 antibody; 15 LIPOXYGENASE RETICULOCYTE ARACHIDONATE antibody; 15 LOX antibody; 15 LOX 1 antibody; 15-LOX antibody; 15LOX 1 antibody; ALOX15 antibody; Arachidonate 15 lipoxygenase antibody; Arachidonate 15-lipoxygenase antibody; Arachidonate omega 6 lipoxygenase antibody; Arachidonate omega-6 lipoxygenase antibody; LOG15 antibody; LOX15_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P16050

Immunogen:Recombinant Human Arachidonate 15-lipoxygenase protein (1-225AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ALOX15

Research Areas:Cancer; Cardiovascular; Metabolism; Signal transduction