AKT1 Monoclonal Antibody

SKU: BT-MCA3906

Size:100μL

Background:The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.

Research_area:Others

Target_protein:AKT1

applications:WB

Reactivity:Human, Mouse, Monkey

Clonality:Monoclonal

Clone ID:3A3

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:AKT1

Immunogen:Purified recombinant fragment of human AKT1 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):56kDa

UniProt accession:P31749

Synonyms:AKT, PKB, RAC, PRKBA, MGC99656, PKB-ALPHA, RAC-ALPHA, AKT1

GeneID:207