ACHE Monoclonal Antibody

SKU: BT-MCA4103

Size:100μL

Background:Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. AChE activity may constitute a sensitive biomarker of RBC ageing in vivo, and thus, may be of aid in understanding the effects of transfusion.

Research_area:Neuroscience, Cardiovascular

Target_protein:ACHE

applications:WB, IHC, FCM

Reactivity:Human, Mouse, Monkey, Rat

Clonality:Monoclonal

Clone ID:3D5E8

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:ACHE

Immunogen:Purified recombinant fragment of human ACHE expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):67.8kDa

UniProt accession:P22303

Synonyms:YT, ACEE, ARACHE, N-ACHE

GeneID:43