Size :50ug
Clone Number:
Aliases:Damage specific DNA binding protein 1 antibody; Damage-specific DNA-binding protein 1 antibody; DDB 1 antibody; DDB p127 subunit antibody; Ddb1 antibody; DDB1_HUMAN antibody; DDBa antibody; DNA damage binding protein 1 antibody; DNA damage-binding protein 1 antibody; DNA damage-binding protein a antibody; HBV X-associated protein 1 antibody; UV damaged DNA binding factor antibody; UV damaged DNA binding protein 1 antibody; UV DDB 1 antibody; UV DDB1 antibody; UV-damaged DNA-binding factor antibody; UV-damaged DNA-binding protein 1 antibody; UV-DDB 1 antibody; X associated protein 1 antibody; XAP 1 antibody; XAP-1 antibody; XAP1 antibody; Xeroderma pigmentosum group E complementing protein antibody; Xeroderma pigmentosum group E-complementing protein antibody; XPCe antibody; XPE antibody; XPE BF antibody; XPE binding factor antibody; XPE-BF antibody; XPE-binding factor antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q16531
Immunogen:Recombinant Human DNA damage-binding protein 1 protein (741-943AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:
Background:Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:FITC
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:DDB1
Research Areas:Epigenetics and Nuclear Signaling