ZFYVE19 Antibody - Cat. #: CSB-PA287149

SKU: CSB-PA287149

Size :100ul

Clone Number:

Aliases:Abscission/NoCut checkpoint regulator antibody; ANCHR antibody; MLL partner containing FYVE domain antibody; MPFYVE antibody; ZFY19_HUMAN antibody; ZFYVE 19 antibody; Zfyve19 antibody; Zinc finger FYVE domain containing protein 19 antibody; Zinc finger FYVE domain-containing protein 19 antibody; Zinc finger FYVE type containing 19 antibody; Zinc finger; FYVE domain containing 19 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96K21

Immunogen:Synthesized peptide derived from internal of Human ZFYVE19.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.

Chinwalla V., Oncogene 22:1400-1410(2003).
Ota T., Nat. Genet. 36:40-45(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ZFYVE19

Research Areas:Cell biology