XBP1 Monoclonal Antibody

SKU: BT-MCA4808

Size:100μL

Background:This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

Research_area:Epigenetics and nuclear signaling

Target_protein:XBP1

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:1C4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:XBP1

Immunogen:Purified recombinant fragment of human XBP1 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):28kDa

UniProt accession:P17861

Synonyms:XBP2, TREB5, XBP1

GeneID:7494