WSS1 Antibody - Cat. #: CSB-PA334485LA01SVG

SKU: CSB-PA334485LA01SVG

Size :50ug

Clone Number:

Aliases:WSS1 antibody; YHR134WDNA-dependent metalloprotease WSS1 antibody; EC 3.4.24.- antibody; DNA damage response protein WSS1 antibody; SUMO-dependent isopeptidase WSS1 antibody; Weak suppressor of SMT3 protein 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

UniProt ID:P38838

Immunogen:Recombinant Saccharomyces cerevisiae DNA-dependent metalloprotease WSS1 protein (1-269AA)

Raised in:Rabbit

Species Reactivity:Saccharomyces cerevisiae

Tested Applications:ELISA

Background:Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:WSS1

Research Areas:Others