VP35 Antibody, Biotin conjugated - Cat. #: CSB-PA856262LD01RCT

SKU: CSB-PA856262LD01RCT

Size :50ug

Clone Number:

Aliases:VP35 antibody; Polymerase cofactor VP35 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)

UniProt ID:Q91DE0

Immunogen:Recombinant Reston ebolavirus Polymerase cofactor VP35 protein (1-329AA)

Raised in:Rabbit

Species Reactivity:Reston ebolavirus

Tested Applications:ELISA

Background:Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:VP35

Research Areas:Others