VIL1 Antibody - Cat. #: CSB-PA025855ESR1HU

SKU: CSB-PA025855ESR1HU

Size :50ul

Clone Number:

Aliases:D2S1471 antibody; OTTHUMP00000164145 antibody; VIL antibody; VIL1 antibody; VILI_HUMAN antibody; Villin 1 antibody; Villin-1 antibody; Villin1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P09327

Immunogen:Recombinant Human Villin-1 protein (1-350AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Epithelial cell-specific Ca2+-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:VIL1

Research Areas:Signal transduction